Two patients who were being treated within the Haeomatology Ward at Craigavon Area Hospital have died within the past 48 hours.
The news has been confirmed by the Southern Health Trust which has expressed sympathy.
A third patient, who was discharged from the hospital, has also passed away with a Covid-19 positive diagnosis.
A spokesperson said: “We can confirm that two patients connected to the Haematology Ward, and who had tested positive with Covid-19, have died within the last 48 hours.
“We are profoundly sorry about these deaths and extend our deepest sympathies to the family and friends of those who have passed away.
“A third patient who had been treated on the Haematology Ward was discharged home and has since sadly passed away with a Covid-19 positive diagnosis but this was not the primary cause of death.
“The total number of patients connected to the Haematology Ward at Craigavon Area Hospital who have tested positive remains at 14.
“Seventeen members of staff have tested positive and are currently off and self-isolating.
“There are 42 staff members have been identified as potential contacts and are currently self-isolating.
“The Ward remains closed to new admissions.”
In relation to Ward 3 South (Medical), a cluster has been confirmed.
The spokesperson added: “Two members of staff and one patient have tested positive. There are currently 14 staff members self-isolating.”
They continued: “There are currently 56 staff who are connected with clusters at Craigavon Area Hospital who are off self isolating. There are other staff across the Trust self-isolating, and these are a mix of clinical and non-clinical staff.
“This will generally relate to family/social contacts where guidelines require a period of 14 day self-isolation. This has been on-going since the start of the pandemic and we expect will continue throughout the winter.”
There have been no further cases in the Emergency Department which is “operating as normal”.
“We encourage any patients who need urgent care to attend,” said the spokesperson.
