Snow and ice are being predicted over three days, between Monday and Wednesday, with the worst of it coming late tomorrow night.
Travel disruption is expected on the roads, especially on Tuesday morning, with snowfall expected through the night, right up until 9am.
Five centimetres of snowfall is expected in some areas across Northern Ireland.
A Met Office spokesperson said: “A spell of rain, sleet and increasingly snow will move east across the UK on Monday night and Tuesday, gradually weakening across England and Wales.
“Some roads and railways may be affected with longer journey times by road, bus and train services.
“As rain, sleet and snow clears Northern Ireland and Scotland overnight, ice may form on some untreated roads, pavements and cycle paths.”
The warning is in place from Monday 8pm until 9am on Wednesday.