The Derrycourtney Road between Caledon and Aughnacloy in Co Tyrone is currently closed following a road traffic collision, police have said.
Motorists are being advised to avoid the area.
A PSNI spokesperson said: “Diversions are in place at the junctions with Knockaginny Road and Dromore Road.
“Please avoid the area and seek an alternative route for your journey.”
No further details are available at this time.