The collision occurred close to Waugh’s crossroads, at the junction of the Ratarnat and Seagahan Roads, shortly before 6pm.
Four fire crews and police are on the scene at present.
The road has been closed in both directions but diversions are in place.
Motorists are being advised to seek an alternative route.
There are no further details at this stage.
You can join our Armagh City & District Facebook group here.
Sign up for our weekly newsletter here.