A man has died a four vehicle road traffic collision on Gosford Road in Markethill.
Eight people have also been taken to hospital for treatment to their injuries.
It happened at around 1.20am this morning, (Saturday).
It is understood that a number of those injured are in a critical condition.
A PSNI spokesperson appealed for information.
They said: “Anyone who may have witnessed the collision or anyone with CCTV or dash cam footage that could assist enquiries, is asked to contact police at Collision Investigation Unit on 101 quoting reference 104 of 04/11/23.
“The road remains closed at this time and motorists are advised to avoid the area and seek an alternative route for their journey.”