A fuel tanker collision has forced the main A4 between Ballygawley and Dungannon to close.
It is understood the large fuel tanker crashed into the partitioning barrier on the inside lane.
Emergency services – including the NI Ambulance Service – were tasked to the scene shortly before 7am.
It is unclear if any other vehicles were involved.
A police spokesperson said: “Motorists are advised that the A4 dual carriageway westbound is now closed between Reaskmore and Cabragh following a road traffic collision. Please seek an alternative route for your journey.”
There are no further details at present.